8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · emollient · stabilizer · thickener
(1r,8r,10s,13r)-5,5,7,9,9,13-Hexamethyl-4,6-Dioxatetracyclo[6.5.1.01,10.03,7]Tetradecane
Molecular Formula
C18H30O2
Molecular Weight
278.4 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in accordance with recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using other active ingredients in conjunction
✕ Avoid If:
- You experience irritation or allergic reactions
- You have a known sensitivity to similar compounds
- Using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C18H30O2 |
| Molecular Weight | 278.4 g/mol |
| Log P | 4.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe for topical use, but patch test first.
Food
Flavoring agents, food additives. Use within established limits; consult guidelines.
Pharmaceutical
Topical ointments, prescription creams. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements, nutraceuticals. Use under professional guidance; monitor for effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly if consumed in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may result in significant irritation or damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but may have increased sensitivity. |
Toxicology Data
3 Endpoints
Safety assessments indicate moderate safety for cosmetic use, with limited data for food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical study | Low sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments indicate moderate safety for cosmetic use, with limited data for food applications.
- CIR supports its use in cosmetics.
- Limited food safety data available.
- Potential for individual sensitivities.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (1r,8r,10s,13r)-5,5,7,9,9,13-Hexamethyl-4,6-Dioxatetracyclo[6.5.1.01,10.03,7]Tetradecane
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of (1r,8r,10s,13r)-5,5,7,9,9,13-Hexamethyl-4,6-Dioxatetracyclo[6.5.1.01,10.03,7]Tetradecane
Year: 2020
Conclusion: Insufficient data to determine safety for food use.
View Full Report →
FDA
Report: Regulatory Status of (1r,8r,10s,13r)-5,5,7,9,9,13-Hexamethyl-4,6-Dioxatetracyclo[6.5.1.01,10.03,7]Tetradecane
Year: 2022
Conclusion: Permitted for use in cosmetics; no specific food regulations.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics; limited data for food use. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further data
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test first.
Consult a healthcare provider before using any products during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:40:12.627343Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.