6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · masking agent · odor neutralizer
Acetyl Hexamethyl Tetralin
Molecular Formula
C18H26O
Molecular Weight
258.4 g/mol
Category
fragrance ingredient
Bottom Line: Acetyl Hexamethyl Tetralin is generally considered safe in cosmetics and household products, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- part of a well-formulated product
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using multiple fragrance products
✕ Avoid If:
- you have known allergies to fragrance ingredients
- you experience irritation after use
- you are using on children without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C18H26O |
| Molecular Weight | 258.4 g/mol |
| Melting Point | 54.5°C |
| Boiling Point | 326.0°C |
| Solubility | In water, 1.25 mg/L, temp not specified |
| Log P | 5.3 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in well-formulated products to minimize irritation risk.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using household products.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for sensitive skin conditions.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Acetyl Hexamethyl Tetralin is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Acetyl Hexamethyl Tetralin may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with Acetyl Hexamethyl Tetralin may cause moderate irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated in healthy adults.
- elderly — Typically well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Typically well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Acetyl Hexamethyl Tetralin is a synthetic fragrance ingredient with limited safety data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Irritation | non-irritating | Human patch test | Low concern for irritation | CIR Safety Assessment (2015) |
| LD50 Oral | Not established | Not tested in animals | Insufficient data for acute toxicity | SCCS Opinion (2018) |
| Sensitization | non-sensitizing | Human clinical study | Low concern for sensitization | FDA Fragrance Ingredient Safety (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Acetyl Hexamethyl Tetralin is a synthetic fragrance ingredient with limited safety data.
- Used primarily in cosmetics and household products.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Acetyl Hexamethyl Tetralin
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Acetyl Hexamethyl Tetralin
Year: 2018
Conclusion: No safety concerns at typical use levels.
View Full Report →
FDA
Report: Fragrance Ingredient Safety
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Acetyl Hexamethyl Tetralin is permitted in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
It is a synthetic fragrance ingredient used in various cosmetic and household products.
While generally safe, individuals with sensitive skin should patch test products containing it.
Some individuals may experience allergic reactions; it's best to test on a small area first.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:57:01.978059Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.