8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · aroma enhancer · solvent · stabilizer
3-Methoxy-7,7-Dimethyl-10-Methylidenebicyclo[4.3.1]Decane
Molecular Formula
C14H24O
Molecular Weight
208.34 g/mol
Category
fragrance compound
Bottom Line: 3-Methoxy-7,7-Dimethyl-10-Methylidenebicyclo[4.3.1]Decane is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using multiple fragrance products
✕ Avoid If:
- you have known allergies to fragrance compounds
- you experience irritation after use
- you are using on children without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H24O |
| Molecular Weight | 208.34 g/mol |
| Log P | 3.6 |
Common Use Cases
5 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents. Limited data on food safety; use cautiously.
Pharmaceutical
Topical formulations. Use with caution; limited safety data available.
Household
Cleaning products, air fresheners. Safe in household products if used correctly.
Supplement
Dietary supplements. Not commonly used; safety data is insufficient.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 3-Methoxy-7,7-Dimethyl-10-Methylidenebicyclo[4.3.1]Decane is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally low to moderate risk, but monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known allergies. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low to Moderate | Elderly may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
3-Methoxy-7,7-Dimethyl-10-Methylidenebicyclo[4.3.1]Decane shows low toxicity in cosmetic applications, though data is limited for food and pharmaceutical uses.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2020) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitive individuals | SCCS Opinion (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
3-Methoxy-7,7-Dimethyl-10-Methylidenebicyclo[4.3.1]Decane shows low toxicity in cosmetic applications, though data is limited for food and pharmaceutical uses.
- Low acute toxicity in cosmetic formulations.
- Limited regulatory assessments for food use.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2021
Conclusion: Requires further investigation for potential sensitization.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2019
Conclusion: Insufficient data to assess safety for food use.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in cosmetics with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics.
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin in low concentrations, though some may experience irritation.
Limited data exists for food safety; use with caution in food applications.
Potential side effects include skin irritation and sensitization in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:26:43.474313Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.