66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · intermediate
CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1R,2S,5R)-
Category
organic compound
Bottom Line: Cyclohexanol, 5-methyl-2-(1-methylethyl)- is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other topical medications
✕ Avoid If:
- you have a known allergy to cyclohexanol derivatives
- you experience irritation upon use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Use within established food safety limits.
Pharmaceutical
Topical medications, prescription creams. Consult a healthcare provider for use in medications.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclohexanol, 5-methyl-2-(1-methylethyl)- is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of this compound can lead to gastrointestinal discomfort and should be avoided unless in regulated amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation; ensure good ventilation when using products containing this substance.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Potential risks to fetal development; use caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- breastfeeding — Generally safe but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cyclohexanol, 5-methyl-2-(1-methylethyl)- has been assessed for safety in various applications, showing moderate toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexanol, 5-methyl-2-(1-methylethyl)- has been assessed for safety in various applications, showing moderate toxicity.
- Used in cosmetics and household products.
- Moderate toxicity profile when used correctly.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexanol Derivatives
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclohexanol
Year: 2018
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Cyclohexanol
Year: 2020
Conclusion: Permitted for use in cosmetics and food under specific regulations.
View Full Report →
Regulatory Status
Global
Cyclohexanol, 5-methyl-2-(1-methylethyl)- is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, cyclohexanol is safe for use in cosmetics when used at recommended concentrations.
If you have sensitive skin, it's advisable to conduct a patch test before using products with cyclohexanol.
Cyclohexanol is permitted in food products within specified safety limits set by regulatory bodies.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:42:54.273938Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.