8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · stabilizer · intermediate · preservative
Ethyl Methylbutyl Ketoxime
Molecular Formula
C8H17NO
Molecular Weight
143.23 g/mol
Category
chemical compound
Bottom Line: Ethyl Methylbutyl Ketoxime is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in well-formulated products
- applied in recommended concentrations
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using on broken or irritated skin
- applying in large amounts
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- using in unregulated products
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C8H17NO |
| Molecular Weight | 143.23 g/mol |
| Log P | 2.5 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair products. Generally safe in cosmetic formulations when used as directed.
Pharmaceutical
Topical ointments, creams. Use in pharmaceuticals is regulated; follow guidelines.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Ethyl Methylbutyl Ketoxime is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Ethyl Methylbutyl Ketoxime may pose moderate risks, especially in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with Ethyl Methylbutyl Ketoxime can cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children are more susceptible to chemical exposure.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by healthy adults.
- elderly — Generally well tolerated, but health factors should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Ethyl Methylbutyl Ketoxime is assessed for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | Not a skin irritant | SCCS Opinion (2016) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl Methylbutyl Ketoxime is assessed for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- Used as a preservative in various formulations.
- Regulatory assessments indicate moderate safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl Methylbutyl Ketoxime
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Ethyl Methylbutyl Ketoxime
Year: 2016
Conclusion: Considered safe for cosmetic use with restrictions.
View Full Report →
FDA
Report: Regulatory Status of Ethyl Methylbutyl Ketoxime
Year: 2020
Conclusion: Permitted in cosmetics; no significant health risks identified.
View Full Report →
Regulatory Status
Global
Ethyl Methylbutyl Ketoxime is permitted in the US and UK, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics.
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
No specific data available.
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution.
It's advisable to avoid use during pregnancy due to limited safety data.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:39:25.333893Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.