67.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
pH adjuster · solvent · fragrance ingredient · preservative
CYCLOHEXANECARBOXYLIC ACID, 2,2,6-TRIMETHYL-, ETHYL
Category
organic acid
Bottom Line: Cyclohexanecarboxylic acid, 2,2,6-trimethyl-, ethyl is generally considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have known allergies to similar compounds
- Using on open wounds or irritated skin
- Exceeding recommended usage levels
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe for topical use; avoid sensitive areas.
Food
Flavoring agents, food preservatives. Considered safe in food applications at regulated levels.
Pharmaceutical
Topical medications, oral formulations. Used in formulations; follow dosage guidelines.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to cyclohexanecarboxylic acid is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of cyclohexanecarboxylic acid may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with cyclohexanecarboxylic acid may cause irritation, indicating moderate risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but health status should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Cyclohexanecarboxylic acid, 2,2,6-trimethyl-, ethyl has been evaluated for safety in cosmetics and food, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2015) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexanecarboxylic acid, 2,2,6-trimethyl-, ethyl has been evaluated for safety in cosmetics and food, showing low toxicity.
- Low acute toxicity in animal studies
- Generally recognized as safe in food applications
- No significant adverse effects reported in cosmetics
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexanecarboxylic Acid
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclohexanecarboxylic Acid
Year: 2018
Conclusion: Considered safe for use in food products.
View Full Report →
FDA
Report: Regulatory Status of Cyclohexanecarboxylic Acid
Year: 2020
Conclusion: Permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Cyclohexanecarboxylic acid is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult your healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:34:40.566572Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.