10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · solvent · emollient
Geranyl Isobutyrate
Molecular Formula
C14H24O2
Molecular Weight
224.34 g/mol
Category
fragrance
Bottom Line: Geranyl Isobutyrate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- not applied to broken skin
- used in well-ventilated areas
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other fragrance products
- you have a history of respiratory issues
✕ Avoid If:
- you are allergic to geranyl compounds
- you experience irritation upon use
- you have a known sensitivity to fragrances
- you are using it in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H24O2 |
| Molecular Weight | 224.34 g/mol |
| Solubility | soluble in most organic solvents; insoluble in water |
| Log P | 4.5 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally recognized as safe when used in food flavoring.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use in medicinal products.
Supplement
Dietary supplements. Limited use; consult a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Geranyl Isobutyrate is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause mild gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: Moderate
Eye contact may cause irritation; rinsing is recommended if contact occurs.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to sensitivity.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- breastfeeding — Generally safe but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Low to Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse reactions. |
| breastfeeding | Low | Limited data; generally considered safe but monitor for reactions. |
| elderly | Low to Moderate | Elderly may have increased sensitivity; monitor for irritation. |
Toxicology Data
3 Endpoints
Geranyl Isobutyrate is a fragrance ingredient with low toxicity and is generally safe for use in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2015) |
| Sensitization | non-sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2016) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Geranyl Isobutyrate is a fragrance ingredient with low toxicity and is generally safe for use in cosmetics and food.
- Low acute toxicity and non-irritating in standard tests.
- Used widely in cosmetic and food products.
- Sensitivity reactions may occur in some individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Geranyl Isobutyrate
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Geranyl Isobutyrate
Year: 2016
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on Geranyl Isobutyrate
Year: 2015
Conclusion: Safe for use in cosmetic products with appropriate restrictions.
View Full Report →
Regulatory Status
Global
Geranyl Isobutyrate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use in cosmetics must comply with SCCS recommendations.
UK
UK GovernmentPERMITTED
Must comply with UK cosmetic regulations.
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Yes, it is permitted as a flavoring agent in food, but should be used in moderation.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:00:08.603495Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.