8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · solvent · stabilizer · thickener
[2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate
Molecular Formula
C15H26O4
Molecular Weight
270.36 g/mol
Category
chemical compound
Bottom Line: Generally, [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate is considered safe for use in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not combined with known irritants
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using other active ingredients in your routine
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation upon first use
- Using on broken or compromised skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O4 |
| Molecular Weight | 270.36 g/mol |
| Log P | 4 |
Common Use Cases
3 Categories
Cosmetic
Moisturizers, sunscreens, serums. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical creams, ointments. Use under medical supervision; monitor for reactions.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but irritation may occur in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse reactions.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- breastfeeding — Generally low risk, but consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Research indicates moderate safety for [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate in cosmetics and supplements.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human clinical study | No sensitization observed | SCCS Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates moderate safety for [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate in cosmetics and supplements.
- Limited data on long-term effects.
- Generally well-tolerated in topical applications.
- Regulatory bodies have not flagged significant concerns.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate
Year: 2022
Conclusion: No safety concerns at specified use levels.
View Full Report →
FDA
Report: Regulatory Status of [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate
Year: 2023
Conclusion: Permitted for use in cosmetics and dietary supplements.
View Full Report →
Regulatory Status
Global
Overall, [2-[1-(3,3-Dimethylcyclohexyl)Ethoxy]-2-Oxoethyl] Propanoate is permitted in major markets with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult your healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:43:24.700206Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.