6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · aroma compound
Trans-Rose Ketone-2
Molecular Formula
C13H20O
Molecular Weight
192.30 g/mol
Category
fragrance
Bottom Line: Trans-Rose Ketone-2 is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using multiple products containing fragrances
✕ Avoid If:
- You have a known allergy to rose-derived ingredients
- You experience irritation upon application
- You are using it in high concentrations without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O |
| Molecular Weight | 192.30 g/mol |
| Boiling Point | 200.0°C |
| Solubility | 1 ml in 10 ml 95% (in ethanol) |
| Log P | 3.5 |
Common Use Cases
3 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, beverages, confectionery. Safe for use in food within established limits.
Supplement
Aromatic supplements. Use cautiously; consult a healthcare provider.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trans-Rose Ketone-2 is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Trans-Rose Ketone-2 may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: Low
Eye contact with Trans-Rose Ketone-2 may cause mild irritation but is generally low risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to sensitive skin and potential for adverse reactions.
- sensitive_skin — Individuals may experience irritation or allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- elderly — Generally well tolerated, but individual sensitivities may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain substances. |
| infants_children | High | Infants and children have more sensitive skin and may react differently. |
| breastfeeding | Low to Moderate | Limited data on effects during breastfeeding; caution is advised. |
| elderly | Low | Elderly individuals may have varying skin sensitivities. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Trans-Rose Ketone-2 has been evaluated for safety in cosmetics and food, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | Non-irritating | Human patch test | No irritation observed | SCCS Opinion (2020) |
| Sensitization | Not sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trans-Rose Ketone-2 has been evaluated for safety in cosmetics and food, showing low toxicity and minimal irritation potential.
- Low acute toxicity in animal studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Trans-Rose Ketone-2
Year: 2018
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Trans-Rose Ketone-2
Year: 2019
Conclusion: Considered safe for use as a flavoring substance.
View Full Report →
SCCS
Report: Opinion on Trans-Rose Ketone-2
Year: 2020
Conclusion: Safe for use in cosmetic products with restrictions.
View Full Report →
Regulatory Status
Global
Trans-Rose Ketone-2 is permitted for use in cosmetics and food across major jurisdictions with some concentration limits. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
Use in cosmetics with concentration limits
United Kingdom
UK GovernmentPERMITTED
Use in cosmetics with concentration limits
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Yes, it is permitted in food applications within established safety limits.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:09:18.856510Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.