6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · antimicrobial agent · antioxidant · skin conditioning agent
Isolongifolanone
Molecular Formula
C15H24O
Molecular Weight
220.35 g/mol
Category
natural compound
Bottom Line: Isolongifolanone is generally considered safe for use in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not combined with known irritants
- Used by individuals without allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are taking other medications or supplements
✕ Avoid If:
- You have a known allergy to Isolongifolanone
- You experience irritation or adverse reactions
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24O |
| Molecular Weight | 220.35 g/mol |
| Log P | 4 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, shampoos. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, herbal teas. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Use under medical supervision; individual reactions may vary.
Supplement
Dietary supplements, herbal capsules. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Isolongifolanone is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Oral ingestion of isolongifolanone may pose moderate risks due to limited data on long-term effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but data on respiratory effects is limited.
ocular
ocular
Risk Level: Very Low
Eye contact with isolongifolanone is generally safe, with minimal irritation reported.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential irritants and allergens.
- pregnant — Limited safety data during pregnancy necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for isolongifolanone exposure. |
| pregnant | Moderate | Limited data on the effects of isolongifolanone during pregnancy. |
| infants_children | High | Children may be more sensitive to isolongifolanone exposure. |
| breastfeeding | Low to Moderate | Limited data on the transfer of isolongifolanone in breast milk. |
| elderly | Low | Elderly individuals generally tolerate isolongifolanone well. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Isolongifolanone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2020) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Isolongifolanone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Generally recognized as safe in cosmetics.
- Low acute toxicity in animal studies.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Isolongifolanone
Year: 2020
Conclusion: Isolongifolanone is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Isolongifolanone
Year: 2021
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: Isolongifolanone is permitted as a food additive.
View Full Report →
Regulatory Status
Global
Isolongifolanone is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Isolongifolanone is a natural compound used in cosmetics and food for its fragrance and potential benefits.
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using Isolongifolanone if you are pregnant or nursing.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:25:00.087503Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.