66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · flavoring agent
ETHANONE, 1-(3-METHYL-2-BENZOFURANYL)-
Category
fragrance compound
Bottom Line: Ethanone, 1-(3-methyl-2-benzofuranyl)- is generally considered safe in regulated amounts, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- used in cosmetic formulations below recommended concentrations
- included in food products within established limits
- applied to intact skin without prior irritation
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or breastfeeding
- you are using multiple products containing fragrances
- you experience any adverse reactions
✕ Avoid If:
- you have a known allergy to fragrance compounds
- you have open wounds or broken skin
- you are using it in high concentrations
- you are in a confined space without ventilation
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in moderation to avoid potential skin irritation.
Food
Flavoring agents, beverages. Generally safe in food applications within regulatory limits.
Pharmaceutical
Topical creams, ointments. Monitor for allergic reactions when used in formulations.
Supplement
Dietary supplements with flavoring. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Ethanone is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Ethanone may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with Ethanone can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known sensitivities. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
Ethanone, 1-(3-methyl-2-benzofuranyl)- has been evaluated for safety in cosmetics and food applications, showing moderate safety.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethanone, 1-(3-methyl-2-benzofuranyl)- has been evaluated for safety in cosmetics and food applications, showing moderate safety.
- Used primarily as a fragrance compound.
- Regulatory bodies have assessed its safety.
- Potential for allergic reactions exists.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethanone
Year: 2015
Conclusion: Ethanone is safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on Ethanone
Year: 2018
Conclusion: Ethanone is acceptable for use in food flavoring at specified limits.
View Full Report →
SCCS
Report: Opinion on Ethanone in Cosmetics
Year: 2019
Conclusion: Ethanone is safe for use in cosmetic products under specific conditions.
View Full Report →
Regulatory Status
Global
Ethanone is permitted for use in cosmetics and food across major jurisdictions with specific guidelines. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use in cosmetics must comply with SCCS recommendations.
UK
UK GovernmentPERMITTED
Must comply with UK regulations.
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Ethanone is generally safe in cosmetics at recommended concentrations, though individual reactions may vary.
Yes, Ethanone is permitted in food flavoring within established limits by regulatory bodies.
If irritation occurs, discontinue use immediately and consult a healthcare professional for advice.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T19:02:23.180481Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.