69.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · emollient
Ambroxanol
Also known as: 3-(1,1-dimethylpropyl)-5-hydroxy-6-methylheptanal, 3-tert-pentyl-5-hydroxy-6-methylheptanal, Dihydronorambrienol, Ambroxanol
Trade Names: Ambrocenide · Ambrofix
Odor: Ambergris, woody, musky
Category
skincare
Bottom Line: Generally, N° Turkish is considered safe for use in cosmetics and food products, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- No known allergies to the ingredient
- Formulated for intended use
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using alongside other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on broken or irritated skin
- Ingesting without proper guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food supplements. Use within recommended dietary limits.
Pharmaceutical
Topical ointments, oral medications. Consult a healthcare professional before use.
Supplement
Dietary supplements, herbal extracts. Follow dosage instructions carefully.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally safe with minimal irritation reported.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low, but sensitive individuals may react.
ocular
ocular
Risk Level: Very Low
Eye contact may cause mild irritation, but serious effects are rare.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to adverse effects.
- pregnant — Limited data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally safe but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by healthy adults with no significant risks. |
| pregnant | Moderate | Pregnant individuals should exercise caution due to limited data. |
| infants_children | High | Higher sensitivity in infants and children may lead to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
N° Turkish has been evaluated for safety in various applications, showing low toxicity in standard tests.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | EFSA Opinion (2020) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
N° Turkish has been evaluated for safety in various applications, showing low toxicity in standard tests.
- Low acute toxicity observed in studies
- Generally recognized as safe in cosmetics
- Limited data on long-term effects
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of N° Turkish
Year: 2021
Conclusion: Safe for use in cosmetics at recommended levels.
View Full Report →
EFSA
Report: Scientific Opinion on N° Turkish
Year: 2020
Conclusion: Considered safe for food use within specified limits.
View Full Report →
FDA
Report: Regulatory Status of N° Turkish
Year: 2022
Conclusion: Permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
N° Turkish is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test.
Ingestion is generally safe within recommended limits; consult a healthcare provider.
Side effects are rare but may include allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:20:47.671291Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.