9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · emulsifier
Ambergris Tincture
Also known as: Ambergris Extract, Ambergris Infusion
Trade Names: Various trade names depending on the dilution and supplier
Odor: Complex, marine, animalic, slightly sweet, earthy, tobacco-like
Molecular Formula
C13H20O
Molecular Weight
192.30 g/mol
Category
preservation
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
- Formulated for intended use
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You are using other active ingredients
- You have allergies to similar compounds
✕ Avoid If:
- You experience irritation or allergic reactions
- You have a known allergy to the ingredient
- You are using on children without guidance
- You are using in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O |
| Molecular Weight | 192.30 g/mol |
| Solubility | Soluble (in ethanol) |
| Log P | 3.2 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe for topical use, but patch test first.
Food
Flavoring agents, food preservatives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, oral medications. Use as directed by healthcare professionals.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks, particularly at high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally very low risk with minor irritation possible.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects due to developing systems.
- pregnant — Potential risks to fetal development necessitate caution.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- breastfeeding — Typically safe with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure. |
| pregnant | Moderate | Pregnant individuals may have increased sensitivity to substances. |
| infants_children | High | Infants and children are more vulnerable to adverse effects. |
| breastfeeding | Low to Moderate | Substances can transfer through breast milk; caution is advised. |
| elderly | Moderate | Elderly individuals may have decreased metabolic rates. |
Toxicology Data
3 Endpoints
Evidence suggests moderate safety for cosmetic and food applications, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Non-irritating | EFSA Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization Test | Not a sensitizer | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evidence suggests moderate safety for cosmetic and food applications, though individual reactions may vary.
- Generally safe in cosmetics and food
- Regulatory bodies have assessed its safety
- Monitor for individual sensitivities
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ingredient
Year: 2020
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2019
Conclusion: Considered safe for use in food applications.
View Full Report →
FDA
Report: Food Ingredient Safety Review
Year: 2021
Conclusion: Generally recognized as safe when used as intended.
View Full Report →
Regulatory Status
Global
Overall, the ingredient is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, some individuals may experience irritation or allergies. Patch testing is recommended.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if you experience any adverse reactions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:11:32.875452Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.