10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · skin conditioning agent · fragrance ingredient
Cyclohexyl 2-Hydroxybenzoate
Molecular Formula
C13H16O3
Molecular Weight
220.26 g/mol
Category
cosmetic
Bottom Line: Cyclohexyl 2-Hydroxybenzoate is generally considered safe for use in cosmetics, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below 1%
- Not applied to broken skin
- Used in well-formulated cosmetic products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- You are pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation or adverse reactions
- Using on open wounds or mucous membranes
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H16O3 |
| Molecular Weight | 220.26 g/mol |
| Log P | 4.2 |
Common Use Cases
2 Categories
Cosmetic
Facial creams, sunscreens, moisturizers, shampoos. Generally safe when used as directed in cosmetic formulations.
Pharmaceutical
Topical ointments, creams. Use with caution; consult a healthcare provider for medical products.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclohexyl 2-Hydroxybenzoate is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; moderate caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but prolonged exposure should be avoided.
ocular
ocular
Risk Level: High
Eye contact may cause irritation; immediate rinsing is recommended if contact occurs.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential irritants and allergens.
- pregnant — Limited data on safety during pregnancy; caution is warranted.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- elderly — Generally well tolerated, but individual reactions may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for skin reactions. |
Toxicology Data
3 Endpoints
Cyclohexyl 2-Hydroxybenzoate is assessed for safety in cosmetics, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2020) |
| Sensitization | non-sensitizing | Human repeated insult patch test | No sensitization reactions | FDA Regulatory Status (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexyl 2-Hydroxybenzoate is assessed for safety in cosmetics, showing low toxicity and minimal irritation potential.
- Low acute toxicity observed in studies.
- Minimal skin irritation reported.
- Generally recognized as safe in cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexyl 2-Hydroxybenzoate
Year: 2018
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Cyclohexyl 2-Hydroxybenzoate
Year: 2020
Conclusion: Considered safe for cosmetic use under specified conditions.
View Full Report →
FDA
Report: Regulatory Status of Cyclohexyl 2-Hydroxybenzoate
Year: 2021
Conclusion: Permitted for use in cosmetics; no significant safety concerns.
View Full Report →
Regulatory Status
Global
Cyclohexyl 2-Hydroxybenzoate is permitted for use in cosmetics across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in some individuals; patch testing is recommended.
Consult a healthcare provider before using products containing this ingredient.
It is commonly found in facial creams, sunscreens, and moisturizers.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:59:51.192872Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.