6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
flavoring agent · fragrance ingredient · solvent · stabilizer
Cis-Tetrahydro-6-Pent-2-Enyl-Pyran-2-One
Molecular Formula
C10H16O2
Molecular Weight
168.23 g/mol
Category
chemical compound
Bottom Line: Cis-Tetrahydro-6-Pent-2-Enyl-Pyran-2-One is generally considered safe in cosmetics and food, though caution is advised with sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have known allergies to similar compounds
- you experience irritation or adverse reactions
- you are using on children without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H16O2 |
| Molecular Weight | 168.23 g/mol |
| Solubility | soluble in alcohol and ether; insoluble in water and fat |
| Log P | 2.4 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use, but patch test recommended.
Food
Flavoring agents, food additives. Generally recognized as safe when used in food applications.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision, especially in sensitive populations.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cis-Tetrahydro-6-Pent-2-Enyl-Pyran-2-One shows low dermal irritation potential based on available studies.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks, particularly at higher doses, due to limited toxicity data.
inhalation
inhalation
Risk Level: Insufficient Data
Inhalation safety data is insufficient to draw definitive conclusions about risks.
ocular
ocular
Risk Level: Low to Moderate
Ocular exposure may cause mild irritation; however, data is limited for severe effects.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures; potential for adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated but should be monitored for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential risks should be considered. |
| infants_children | High | Children may be more sensitive to chemical exposures; caution is advised. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; potential effects on infants are unknown. |
| elderly | Low | Elderly individuals may have different sensitivities; monitor for adverse effects. |
Toxicology Data
3 Endpoints
Cis-Tetrahydro-6-Pent-2-Enyl-Pyran-2-One has limited safety data but is generally regarded as safe in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical study | Low concern for sensitization | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cis-Tetrahydro-6-Pent-2-Enyl-Pyran-2-One has limited safety data but is generally regarded as safe in cosmetics and food.
- Limited studies on long-term effects.
- Generally recognized as safe in food applications.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cosmetic Ingredients
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2020
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Food Ingredients and Their Safety
Year: 2022
Conclusion: No known safety concerns when used as directed.
View Full Report →
Regulatory Status
Global
Cis-Tetrahydro-6-Pent-2-Enyl-Pyran-2-One is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, yes, but patch testing is recommended for sensitive skin.
Consult a healthcare provider before use during pregnancy.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:48:06.309449Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.