8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
(5z)-3-Methylcyclotetradec-5-En-1-One
Molecular Formula
C15H26O
Molecular Weight
222.37 g/mol
Category
organic compound
Bottom Line: Generally regarded as safe when used appropriately, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food products within regulatory limits
- Used in pharmaceuticals as directed by a healthcare professional
⚠ Use with Awareness If:
- You have sensitive skin or allergies to similar compounds
- You are pregnant or breastfeeding
- You are using other products containing similar ingredients
✕ Avoid If:
- You have a known allergy to this compound
- You experience irritation or adverse reactions upon use
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O |
| Molecular Weight | 222.37 g/mol |
| Log P | 4.9 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, food additives. Safe for consumption within established limits.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision to avoid adverse effects.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (5z)-3-Methylcyclotetradec-5-En-1-One is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (5z)-3-Methylcyclotetradec-5-En-1-One may pose moderate risks based on limited studies.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally of very low risk, but irritation may occur in sensitive individuals.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects from chemical exposure.
- pregnant — Potential for altered sensitivity and effects on fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated but may require caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure compared to vulnerable populations. |
| pregnant | Moderate | Pregnant individuals may have altered sensitivities to chemicals. |
| infants_children | High | Children are more susceptible to chemical exposure effects. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Elderly individuals may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
Research indicates (5z)-3-Methylcyclotetradec-5-En-1-One is generally safe for use in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | EFSA Opinion (2022) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates (5z)-3-Methylcyclotetradec-5-En-1-One is generally safe for use in cosmetics and food.
- Regulatory bodies have assessed its safety.
- Low toxicity levels reported in studies.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (5z)-3-Methylcyclotetradec-5-En-1-One
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on (5z)-3-Methylcyclotetradec-5-En-1-One
Year: 2022
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of (5z)-3-Methylcyclotetradec-5-En-1-One
Year: 2023
Conclusion: No restrictions on use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Overall, (5z)-3-Methylcyclotetradec-5-En-1-One is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally considered safe in cosmetics when used as directed, though individual reactions may vary.
Yes, it is safe for consumption within established limits, but check for allergies.
Some individuals may experience irritation or allergic reactions; consult a healthcare provider if unsure.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:46:15.933603Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.