66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · thickener · stabilizer · solvent
CYCLOHEXANEPROPANOIC ACID, 2-PROPENYL ESTER
Category
chemical compound
Bottom Line: Cyclohexanepropanoic acid, 2-propenyl ester is generally considered safe in cosmetics and food, though caution is advised with sensitive skin.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Formulated for non-sensitive skin types
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
- Pregnant or breastfeeding
✕ Avoid If:
- You have known allergies to similar compounds
- Using on broken or irritated skin
- Ingesting in large quantities
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food preservatives. Used within regulatory limits; consult guidelines.
Pharmaceutical
Topical ointments, oral medications. Safety evaluated in specific formulations; follow guidelines.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to cyclohexanepropanoic acid, 2-propenyl ester is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or prolonged exposure.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation; caution is advised to prevent exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased adverse effects.
- pregnant — Limited safety data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- breastfeeding — Generally low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children may increase risk. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cyclohexanepropanoic acid, 2-propenyl ester has been evaluated for safety in cosmetics and food, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexanepropanoic acid, 2-propenyl ester has been evaluated for safety in cosmetics and food, showing low toxicity.
- Low acute toxicity in animal studies
- Generally recognized as safe in regulated uses
- Limited skin irritation potential
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexanepropanoic Acid, 2-Propenyl Ester
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclohexanepropanoic Acid, 2-Propenyl Ester
Year: 2018
Conclusion: Considered safe for use in food applications within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Cyclohexanepropanoic Acid, 2-Propenyl Ester
Year: 2020
Conclusion: Permitted for use in food and cosmetics under specific regulations.
View Full Report →
Regulatory Status
Global
Cyclohexanepropanoic acid, 2-propenyl ester is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, yes, but patch testing is recommended for sensitive skin.
Caution is advised; consult a healthcare provider if you have known allergies.
Side effects are rare but may include skin irritation in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:36:28.476538Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.