6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antimicrobial · stabilizer
Ambreine
Also known as: Nerolidol, alpha-Nerolidol
Odor: Floral, woody, citrusy, fresh, slightly amber
Molecular Formula
C13H16O2
Molecular Weight
204.26 g/mol
Category
preservation
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- No known allergies to the ingredient
- Formulated for intended use
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You experience irritation or adverse reactions
- Using on broken or damaged skin
- You have a known allergy to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H16O2 |
| Molecular Weight | 204.26 g/mol |
| Log P | 2.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food preservatives. Considered safe in food applications within regulated limits.
Pharmaceutical
Topical ointments, oral medications. Use as directed; monitor for side effects.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally safe with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks, including gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low, but prolonged exposure may cause irritation.
ocular
ocular
Risk Level: High
Ocular exposure can lead to significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- elderly — Generally safe, but should be monitored for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant adverse effects. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children may lead to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for any unusual reactions. |
Toxicology Data
3 Endpoints
Multiple assessments indicate moderate safety for cosmetic and food use, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Multiple assessments indicate moderate safety for cosmetic and food use, though individual reactions may vary.
- CIR supports its use in cosmetics.
- EFSA has evaluated its safety in food applications.
- No significant concerns reported in clinical studies.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ingredient
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Food Safety
Year: 2020
Conclusion: Considered safe for use in food products within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Ingredient
Year: 2022
Conclusion: Permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Ingredient is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult with a healthcare provider before using any new products during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:13:39.187519Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.