10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · solvent · stabilizer
2-Methyl-4-(2,2,3-Trimethyl-3-Cyclopentenyl)-2-Buten-1-Ol
Molecular Formula
C13H22O
Molecular Weight
194.31 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe when used in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Formulated in products designed for topical application
- Not used by individuals with known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- Pregnant or nursing, consult a healthcare provider
✕ Avoid If:
- You experience irritation or allergic reactions
- Using in high concentrations without proper guidance
- You have a known allergy to this ingredient
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H22O |
| Molecular Weight | 194.31 g/mol |
| Log P | 3.1 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, scented lotions, hair products. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, beverages, baked goods. Used in food products, typically safe in regulated amounts.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this ingredient is generally low risk for most individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or sensitive individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: Moderate
Eye contact may cause moderate irritation; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential risks should be considered. |
| infants_children | High | Children may be more sensitive to chemical exposures; caution is warranted. |
| breastfeeding | Insufficient Data | Safety during breastfeeding is not well established; limited studies available. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation or allergic reactions. |
Toxicology Data
3 Endpoints
2-Methyl-4-(2,2,3-Trimethyl-3-Cyclopentenyl)-2-Buten-1-Ol is generally safe in cosmetics and food, with some caution advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data for acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2018) |
| Sensitization | Not sensitizing | Human sensitization study | No sensitization observed | CIR Safety Assessment (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-Methyl-4-(2,2,3-Trimethyl-3-Cyclopentenyl)-2-Buten-1-Ol is generally safe in cosmetics and food, with some caution advised.
- Regulatory bodies have assessed its safety.
- Commonly used in fragrances and flavorings.
- Individual reactions may vary.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring Group Evaluation
Year: 2019
Conclusion: Considered safe for use in food flavorings.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Permitted for use in food products under specific conditions.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Used within established limits
European Union
European CommissionPERMITTED
Allowed in cosmetics and food flavorings
United Kingdom
UK GovernmentPERMITTED
Used in compliance with safety regulations
Canada
Health CanadaPERMITTED
Allowed in cosmetics and food products
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Consult your healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:11:56.525108Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.