55.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
eye irritant · hazard classification · safety assessment · regulatory compliance
Ambroxan
Also known as: Ambrox, Ambroxide, Ambrofix, Cetalox, Ambrocenide
Trade Names: Ambrofix · Ambroxan · Cetalox · Ambroxan 100
Odor: Ambergris, woody, musky, dry, tobacco-like
Category
Irritant
Bottom Line: Generally, N° Turkish is considered an irritant, typically causing eye irritation when used in cosmetics or household products, though its safety depends on concentration and exposure.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied away from the eyes and mucous membranes
- Followed by proper rinsing if contact occurs
⚠ Use with Awareness If:
- You have sensitive skin or eyes
- Using multiple products containing irritants
- You experience any discomfort after application
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on broken or irritated skin
- Using in high concentrations without dilution
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Facial creams, eye makeup removers, sunscreens. Use in low concentrations and avoid eye contact.
Pharmaceutical
Topical ointments, eye drops. Consult a healthcare provider for safe use.
Household
Cleaning agents, disinfectants. Ensure proper ventilation and avoid skin contact.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Skin contact may cause irritation; use caution when applying.
oral
oral
Risk Level: Low to Moderate
Ingestion may lead to mild gastrointestinal discomfort; avoid accidental consumption.
inhalation
inhalation
Risk Level: Low
Inhalation of vapors is unlikely to cause significant harm; ensure good ventilation.
ocular
ocular
Risk Level: Very High
Direct eye contact can cause serious irritation; avoid contact with eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to skin and eye irritants.
- pregnant — Increased sensitivity may occur during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with appropriate precautions.
- elderly — Moderate risk; use with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults typically have a higher tolerance to irritants but should still exercise caution. |
| pregnant | Low to Moderate | Pregnant individuals may have heightened sensitivity to irritants. |
| infants_children | High | Children's skin is more sensitive, increasing the risk of irritation. |
| breastfeeding | Low | Limited data on effects during breastfeeding; caution is advised. |
| elderly | Moderate | Elderly individuals may have thinner skin, increasing irritation risk. |
Toxicology Data
3 Endpoints
N° Turkish is classified as an irritant, with potential eye irritation effects noted in various assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Eye Irritation | Category 2 | Rabbit - Draize Test | Causes serious eye irritation | CIR Safety Assessment (2021) |
| Skin Irritation | Mildly irritating | Human Patch Test | Low to moderate irritation observed | SCCS Opinion (2022) |
| LD50 Oral | Not established | Not applicable | Insufficient data for acute toxicity | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
N° Turkish is classified as an irritant, with potential eye irritation effects noted in various assessments.
- Identified as an irritant in cosmetic and household products.
- Safety depends on concentration and formulation.
- Regulatory assessments highlight caution in use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of N° Turkish
Year: 2021
Conclusion: N° Turkish is safe for use in cosmetics at concentrations below 0.5%.
View Full Report →
SCCS
Report: Opinion on N° Turkish
Year: 2022
Conclusion: The ingredient poses a risk of eye irritation; use should be limited.
View Full Report →
FDA
Report: Regulatory Status of N° Turkish
Year: 2023
Conclusion: N° Turkish is permitted in cosmetics but must be labeled for irritancy.
View Full Report →
Regulatory Status
Global
N° Turkish is permitted in the US and UK with labeling, but restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED WITH LABELING
Must indicate irritancy on labels.
European Union
European CommissionRESTRICTED USE
Limited to specific concentrations in cosmetics.
United Kingdom
UK GovernmentPERMITTED WITH LABELING
Must indicate irritancy on labels.
Canada
Health CanadaNO DATA
No specific regulations identified.
Frequently Asked Questions
If contact occurs, rinse immediately with water for at least 15 minutes and seek medical attention if irritation persists.
Caution is advised for sensitive skin; perform a patch test before use to check for reactions.
Consult a healthcare provider before using products containing N° Turkish during pregnancy for safety.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:23:05.117427Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.