10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
Oxacycloheptadec-10-En-2-One
Molecular Formula
C16H28O2
Molecular Weight
252.39 g/mol
Category
chemical compound
Bottom Line: Generally, Oxacycloheptadec-10-En-2-One is considered safe for use in cosmetics and supplements, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- No known allergies to similar compounds
- Formulated for topical application only
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to this ingredient
- Using on broken or irritated skin
- Using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O2 |
| Molecular Weight | 252.39 g/mol |
| Boiling Point | 185.0°C |
| Solubility | Soluble (in ethanol) |
| Log P | 5.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, moisturizers. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Use within established food safety guidelines.
Pharmaceutical
Topical medications, prescription creams. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements, nutraceuticals. Follow dosage recommendations; consult a doctor if unsure.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Oxacycloheptadec-10-En-2-One is generally safe for skin contact, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: Very Low
Eye contact is generally safe, with minimal irritation reported in available studies.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited safety data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- elderly — Generally well tolerated, but monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically tolerate Oxacycloheptadec-10-En-2-One well, with few adverse effects. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Elderly individuals generally tolerate this ingredient well. |
Toxicology Data
3 Endpoints
Oxacycloheptadec-10-En-2-One has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Oxacycloheptadec-10-En-2-One has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in cosmetics.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Oxacycloheptadec-10-En-2-One
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Oxacycloheptadec-10-En-2-One
Year: 2020
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Oxacycloheptadec-10-En-2-One
Year: 2022
Conclusion: No restrictions on use in cosmetics and food.
View Full Report →
Regulatory Status
Global
Oxacycloheptadec-10-En-2-One is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult a healthcare provider before using any new products during pregnancy.
Discontinue use immediately and consult a dermatologist if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:29:27.314366Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.