67.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
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fragrance ingredient · solvent · preservative · stabilizer
BENZENEACETALDEHYDE, CYCLIC ACETAL WITH 1,2,3-
Category
chemical compound
Bottom Line: Benzeneacetaldehyde, cyclic acetal is generally considered safe in regulated uses, though caution is advised based on concentration and application.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied in well-ventilated areas for household products
- Used in food applications within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using products in poorly ventilated spaces
- Consuming food products with unknown concentrations
✕ Avoid If:
- You are pregnant or nursing
- You have a history of respiratory issues
- Using in high concentrations without proper guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, shampoos, body lotions. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food preservatives. Ensure compliance with food safety regulations.
Pharmaceutical
Topical medications, oral formulations. Follow dosage guidelines to avoid adverse effects.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to reduce inhalation risk.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzeneacetaldehyde is generally low risk, but irritation may occur.
oral
oral
Risk Level: Moderate
Ingestion of benzeneacetaldehyde may pose moderate risks, including gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but prolonged exposure may lead to respiratory issues.
ocular
ocular
Risk Level: Moderate
Eye contact with benzeneacetaldehyde can cause irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Benzeneacetaldehyde, cyclic acetal has been evaluated for safety in various applications, showing low toxicity in regulated uses.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzeneacetaldehyde, cyclic acetal has been evaluated for safety in various applications, showing low toxicity in regulated uses.
- Generally recognized as safe in low concentrations.
- Potential irritant at higher levels.
- Regulatory assessments support safe use in cosmetics and food.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzeneacetaldehyde
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on Benzeneacetaldehyde
Year: 2018
Conclusion: Acceptable daily intake established for food use.
View Full Report →
FDA
Report: Regulatory Status of Benzeneacetaldehyde
Year: 2020
Conclusion: Permitted for use in food and cosmetics under specific conditions.
View Full Report →
Regulatory Status
Global
Benzeneacetaldehyde is permitted for use in cosmetics and food across major jurisdictions with specific limits. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use within established limits
European Union
European CommissionPERMITTED
Use in cosmetics and food within limits
United Kingdom
UK GovernmentPERMITTED
Similar to EU regulations
Canada
Health CanadaPERMITTED
Use within established limits
Frequently Asked Questions
Generally, yes, when used in low concentrations as per regulatory guidelines.
Be cautious if you have sensitive skin or respiratory issues, and check product labels.
Yes, it is permitted but must comply with established safety limits.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:58:58.762299Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.