8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · intermediate · stabilizer
8-Cyclohexadecenone
Molecular Formula
C16H28O
Molecular Weight
236.39 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- used in well-formulated products
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have known allergies to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O |
| Molecular Weight | 236.39 g/mol |
| Log P | 5.6 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use in cosmetics.
Food
Flavoring agents, food preservatives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Use in pharmaceuticals is regulated; consult a professional.
Supplement
Dietary supplements. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 8-Cyclohexadecenone is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 8-Cyclohexadecenone may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Insufficient Data
Limited data exists on ocular exposure, making risk assessment challenging.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse reactions.
- pregnant — Moderate risk due to potential sensitivity and developmental concerns.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- breastfeeding — Generally low to moderate risk, but caution is recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain substances. |
| infants_children | High | Children may be more susceptible to adverse effects due to their developing systems. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
Toxicology Data
4 Endpoints
8-Cyclohexadecenone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | CIR Safety Assessment (2015) |
| Eye Irritation | mild irritation | Rabbit - Eye Irritation Test | Mild irritant | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
8-Cyclohexadecenone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally safe for cosmetic use.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 8-Cyclohexadecenone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on 8-Cyclohexadecenone
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Permitted for use in food applications under specific conditions.
View Full Report →
Regulatory Status
Global
8-Cyclohexadecenone is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use in food and cosmetics under specific conditions.
European Union
European CommissionPERMITTED
Allowed in cosmetics and food flavoring.
United Kingdom
UK GovernmentPERMITTED
Regulated under UK food and cosmetic laws.
Canada
Health CanadaPERMITTED
Allowed in cosmetics and food with guidelines.
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Possible side effects include irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:50:53.982220Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.