57.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · masking agent · odorant · sensory enhancer
Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde
Molecular Formula
C13H22O2
Molecular Weight
210.31 g/mol
Category
fragrance ingredient
Bottom Line: Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde is generally considered safe in cosmetics, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- part of a well-formulated product
⚠ Use with Awareness If:
- you have sensitive skin
- you are using multiple fragrance products
- you have a history of allergies
✕ Avoid If:
- you are pregnant or nursing
- you have known fragrance allergies
- you experience irritation after use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H22O2 |
| Molecular Weight | 210.31 g/mol |
| Log P | 1.7 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to minimize potential irritation.
Household
Air fresheners, cleaning products. Ensure good ventilation when using products containing this ingredient.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if you have skin sensitivities.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Insufficient Data
Limited data on oral ingestion safety; potential toxicity is not well characterized.
inhalation
inhalation
Risk Level: Moderate
Inhalation may pose moderate risks, particularly in poorly ventilated areas or with high concentrations.
ocular
ocular
Risk Level: Low to Moderate
Eye contact may cause mild irritation; caution is advised to avoid exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and allergic reactions.
- sensitive_skin — Increased likelihood of adverse skin reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- breastfeeding — Generally safe with caution advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more susceptible to potential irritants and allergens. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde is a synthetic fragrance ingredient with potential sensitization effects.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Sensitization | Moderate sensitizer | Human patch test | GHS Category 1B | CIR Safety Assessment (2015) |
| LD50 Oral | Not established | N/A | Insufficient data | SCCS Opinion (2018) |
| Eye Irritation | Non-irritating | Rabbit eye test | Not classified | FDA Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde is a synthetic fragrance ingredient with potential sensitization effects.
- Used primarily in cosmetic and household products.
- May cause allergic reactions in some individuals.
- Regulatory assessments indicate moderate safety concerns.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde
Year: 2018
Conclusion: Not safe for use in cosmetics above 0.5% due to sensitization potential.
View Full Report →
FDA
Report: Fragrance Ingredient Review
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Hydroxyisohexyl-3-Cyclohexene Carboxaldehyde is permitted in the US but restricted in the EU and UK. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Max 0.5% in cosmetics
United Kingdom
UK GovernmentRESTRICTED
Max 0.5% in cosmetics
Canada
Health CanadaNO_DATA
None
Frequently Asked Questions
It is a synthetic fragrance ingredient used in cosmetics and household products.
It may cause irritation or allergic reactions in sensitive individuals, so caution is advised.
Regulations vary; it is restricted in the EU and UK but permitted in the US.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:12:08.481796Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.