66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · fragrance component · stabilizer
ETHANONE, 1-(2,3,4,7,8,8A-HEXAHYDRO-3,6,8,8-
Category
chemical compound
Bottom Line: Ethanone, 1-(2,3,4,7,8,8A-hexahydro-3,6,8,8-) is generally considered safe when used in regulated amounts, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in cosmetic formulations below recommended concentrations
- applied to intact skin without prior irritation
- used in food products within established limits
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using on broken skin
- you are consuming in unregulated amounts
Chemical Properties
| Property | Value |
|---|
Common Use Cases
6 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, food additives. Safe in food products within established limits.
Pharmaceutical
Topical medications, prescription creams. Use under medical supervision for pharmaceuticals.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to avoid irritation.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Veterinary
Pet grooming products, animal medications. Use veterinary products as directed.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to ethanone is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of ethanone can pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may lead to respiratory irritation, particularly in high concentrations.
ocular
ocular
Risk Level: High
Eye contact with ethanone can cause significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to chemical exposure due to developing systems.
- pregnant — Increased sensitivity to chemicals may affect fetal development.
- sensitive_skin — Prone to irritation and allergic reactions from skin contact.
✔ Well-Tolerated Groups
- general_adult — Typically have a higher tolerance to ethanone exposure.
- breastfeeding — Generally safe with precautions, but limited data available.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance to ethanone exposure compared to sensitive populations. |
| pregnant | Moderate | Pregnant individuals may have increased sensitivity to chemicals, including ethanone. |
| infants_children | Very High | Children are more vulnerable to chemical exposures due to their developing systems. |
| breastfeeding | Low to Moderate | Limited data on ethanone transfer through breast milk; caution is advised. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation from dermal exposure. |
Toxicology Data
3 Endpoints
Ethanone, 1-(2,3,4,7,8,8A-hexahydro-3,6,8,8-) has been evaluated for safety in various applications, showing moderate safety profiles.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Draize test | No significant irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethanone, 1-(2,3,4,7,8,8A-hexahydro-3,6,8,8-) has been evaluated for safety in various applications, showing moderate safety profiles.
- Used in cosmetics and food with safety assessments.
- Regulatory bodies have set concentration limits.
- Potential for irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethanone
Year: 2021
Conclusion: Ethanone is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Ethanone
Year: 2020
Conclusion: Ethanone is safe for use as a food flavoring agent within specified limits.
View Full Report →
FDA
Report: Ethanone Regulatory Status
Year: 2022
Conclusion: Ethanone is permitted in food and cosmetic products under specific regulations.
View Full Report →
Regulatory Status
Global
Ethanone is generally permitted in cosmetics and food across major jurisdictions with specific usage limits. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use within established limits.
European Union
European CommissionPERMITTED
Use in cosmetics and food within specified limits.
United Kingdom
UK GovernmentPERMITTED
Use in cosmetics and food within specified limits.
Canada
Health CanadaPERMITTED
Use within established limits.
Frequently Asked Questions
Ethanone is generally safe in cosmetics when used as directed, but check for skin sensitivity.
Ethanone is permitted in food products within established limits, but moderation is key.
If irritation occurs, discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:59:46.089123Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.