9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · masking agent · odorant · solvent
Dihydro Pentamethylindanone
Molecular Formula
C14H22O
Molecular Weight
206.32 g/mol
Category
fragrance
Bottom Line: Dihydro Pentamethylindanone is generally considered safe in cosmetics, though some individuals may experience sensitivity. Always check product labels.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- applied in low concentrations
- not used on broken skin
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using multiple fragrance products
✕ Avoid If:
- you have known allergies to similar fragrance compounds
- you experience irritation or adverse reactions
- you are using products for children
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H22O |
| Molecular Weight | 206.32 g/mol |
| Log P | 3.3 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics when used as directed.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to minimize inhalation risks.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if unsure about use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dihydro Pentamethylindanone is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; limited data on long-term effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: Low
Eye contact may cause mild irritation; generally not severe.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low risk.
- elderly — Typically low risk but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure compared to vulnerable groups. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Elderly individuals may have varying sensitivities; monitor for reactions. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Dihydro Pentamethylindanone has been evaluated for safety in cosmetic applications, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2016) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Status (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Dihydro Pentamethylindanone has been evaluated for safety in cosmetic applications, showing low toxicity and minimal irritation potential.
- Low acute toxicity in animal studies.
- Minimal skin irritation reported.
- Used safely in various cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Dihydro Pentamethylindanone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Dihydro Pentamethylindanone
Year: 2016
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
FDA
Report: Regulatory Status of Dihydro Pentamethylindanone
Year: 2021
Conclusion: Permitted for use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
Dihydro Pentamethylindanone is permitted for use in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult your healthcare provider before using products with this ingredient during pregnancy.
It is commonly found in perfumes, lotions, and household cleaning products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:13:44.220047Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.