56.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance · stabilizer · emollient
BICYCLO[3.1.0]HEXAN, 1-ISOPROPYL, 4-METHYLENE-
Category
organic compound
Bottom Line: Generally, bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene- is considered safe in regulated uses, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in concentrations below regulatory limits
- applied to intact skin
- not ingested in food products
- used in well-formulated cosmetic products
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other active ingredients
- applying to broken or irritated skin
- considering use in food products
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- you experience irritation upon application
- using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair products. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food additives. Use in food should comply with safety regulations.
Pharmaceutical
Topical medications, prescription creams. Consult a healthcare provider for pharmaceutical use.
Supplement
Dietary supplements, herbal products. Safety in supplements is less established; use with caution.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on effects during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low risk.
- elderly — Typically low to moderate risk, but monitor closely.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known severe adverse effects. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene- shows moderate safety in cosmetic and food applications based on available assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | non-sensitizing | Human sensitization study | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene- shows moderate safety in cosmetic and food applications based on available assessments.
- Moderate safety profile in cosmetics.
- Limited data on food safety.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene-
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of Bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene- as a food additive
Year: 2020
Conclusion: Insufficient data to determine safety in food applications.
View Full Report →
FDA
Report: Regulatory Status of Bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene-
Year: 2022
Conclusion: Generally recognized as safe in cosmetics; no specific food approval.
View Full Report →
Regulatory Status
Global
Bicyclo[3.1.0]hexan, 1-isopropyl, 4-methylene- is permitted in cosmetics but has restrictions in food applications. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in food applications
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
No specific regulations found
Frequently Asked Questions
Generally, it is considered safe for skin use in cosmetics when used as directed.
Caution is advised; perform a patch test before full application.
It has limited approval for food use; consult regulations before use.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:24:01.612886Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.