66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · fragrance component · stabilizer
CYCLOHEXANOL, 3-(5,5,6-TRIMETHYLBICYCLO[2.2.1]HEPT-2-
Category
chemical compound
Bottom Line: Cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-) is generally considered safe in regulated uses, though caution is advised based on concentration and application.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied to intact skin without irritation
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or nursing women should consult a healthcare provider
✕ Avoid If:
- You have a known allergy to cyclohexanol derivatives
- Using on broken or irritated skin
- Ingesting in large quantities outside of food products
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food preservatives. Generally safe within established food safety limits.
Pharmaceutical
Topical ointments, oral medications. Consult healthcare providers for specific uses.
Household
Cleaning agents, deodorizers. Ensure proper ventilation when using household products.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclohexanol may cause mild irritation upon skin contact in some individuals.
oral
oral
Risk Level: Moderate
Ingestion of cyclohexanol can lead to gastrointestinal discomfort and potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of cyclohexanol vapors may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children are particularly sensitive to chemical exposure.
- pregnant — Pregnant individuals may experience heightened sensitivity.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated by healthy adults.
- elderly — Typically tolerated but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for chemical exposure. |
| pregnant | Moderate | Pregnant individuals may be more sensitive to chemical exposures. |
| infants_children | Very High | Children are more vulnerable to chemical toxicity. |
| breastfeeding | Moderate | Potential for transfer through breast milk is a concern. |
| elderly | Low to Moderate | Elderly individuals may have decreased resilience to chemicals. |
Toxicology Data
3 Endpoints
Cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-) has been evaluated for safety in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | CIR Safety Assessment (2015) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-) has been evaluated for safety in cosmetics and food applications.
- Considered safe in regulated concentrations.
- Potential for skin irritation in sensitive individuals.
- Regulatory bodies support its use in various products.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexanol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclohexanol
Year: 2018
Conclusion: Acceptable daily intake established for food use.
View Full Report →
FDA
Report: Regulatory Status of Cyclohexanol
Year: 2020
Conclusion: Permitted for use in food and cosmetics under specific conditions.
View Full Report →
Regulatory Status
Global
Cyclohexanol is generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use within established limits
European Union
European CommissionPERMITTED
Use in cosmetics and food within safety limits
United Kingdom
UK GovernmentPERMITTED
Use in cosmetics and food within safety limits
Canada
Health CanadaPERMITTED
Use within established limits
Frequently Asked Questions
Cyclohexanol is generally safe in cosmetics when used within recommended concentrations.
Yes, cyclohexanol is permitted in food products under specific safety limits.
Be cautious if you have sensitive skin or allergies, and consult a healthcare provider if pregnant.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:40:08.876335Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.