7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
Oxacyclohexadecenone
Molecular Formula
C15H26O2
Molecular Weight
238.37 g/mol
Category
chemical compound
Bottom Line: Oxacyclohexadecenone is generally considered safe in cosmetics and household products, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- formulated in stable products
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or breastfeeding
- you are using other active ingredients
✕ Avoid If:
- you have known allergies to similar compounds
- you experience irritation or adverse reactions
- the product is not properly labeled
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O2 |
| Molecular Weight | 238.37 g/mol |
| Log P | 5.7 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical ointments, creams. Use under medical supervision; potential for skin irritation.
Household
Cleaning agents, air fresheners. Follow usage instructions; avoid inhalation.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Oxacyclohexadecenone is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; limited data on long-term effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but data on chronic exposure is limited.
ocular
ocular
Risk Level: High
Contact with eyes may cause irritation; caution is advised to prevent exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to irritants and potential toxins.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated; monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate this ingredient with minimal risk. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to potential irritants and toxins. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Elderly individuals typically tolerate this ingredient well. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Oxacyclohexadecenone has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | SCCS Opinion (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Oxacyclohexadecenone has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetic formulations.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Oxacyclohexadecenone
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Oxacyclohexadecenone
Year: 2021
Conclusion: Considered safe for cosmetic use with appropriate labeling.
View Full Report →
FDA
Report: Regulatory Status of Oxacyclohexadecenone
Year: 2022
Conclusion: No restrictions on use in cosmetics; safe at recommended levels.
View Full Report →
Regulatory Status
Global
Oxacyclohexadecenone is permitted for use in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, it may cause irritation in sensitive individuals; patch testing is advised.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:30:20.400897Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.