7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate
Molecular Formula
C12H18O2
Molecular Weight
194.27 g/mol
Category
chemical compound
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on open wounds or irritated skin
- You experience adverse reactions after use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H18O2 |
| Molecular Weight | 194.27 g/mol |
| Log P | 2.9 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, fragrances. Use in moderation and patch test for sensitivity.
Food
Flavoring agents, food additives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements, herbal extracts. Consult with a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate is generally low risk but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may lead to respiratory irritation, particularly in poorly ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; potential risks during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may occur. |
Toxicology Data
3 Endpoints
Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate is generally safe for use in cosmetics and food, with some caution advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate is generally safe for use in cosmetics and food, with some caution advised.
- Regulatory bodies have assessed its safety.
- Potential for skin irritation in sensitive individuals.
- Limited long-term safety data available.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate
Year: 2020
Conclusion: Considered safe for use as a food additive.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: Permitted for use in food products under specific conditions.
View Full Report →
Regulatory Status
Global
Ethyl 2,6,6-Trimethylcyclohexa-1,3-Enecarboxylate is permitted in major jurisdictions with specific guidelines. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use in food and cosmetics under specific conditions.
EU
European CommissionPERMITTED
Allowed in cosmetics and food additives.
UK
UK GovernmentPERMITTED
Regulated under UK food and cosmetic laws.
CA
Health CanadaPERMITTED
Allowed in cosmetics and food products.
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Possible side effects include skin irritation or allergic reactions in some individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:26:30.758468Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.