46.0
ISS Score
Poor — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · emollient
BICYCLO[3.1.1]HEPT-2-ENE-2-ETHANOL, 6,6-DIMETHYL-,
Category
chemical compound
Bottom Line: Generally regarded as safe when used appropriately, though some caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin or open wounds
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using other products with similar ingredients
✕ Avoid If:
- You have a known allergy to this compound
- You experience irritation or adverse reactions
- Using on children without consulting a healthcare provider
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair products. Generally safe in cosmetic formulations at low concentrations.
Food
Flavoring agents, food additives. Use in food is limited; consult regulations.
Pharmaceutical
Topical medications, prescription creams. Safety in pharmaceuticals is assessed on a case-by-case basis.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to bicyclo[3.1.1]hept-2-ene-2-ethanol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of bicyclo[3.1.1]hept-2-ene-2-ethanol may pose moderate risks based on limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with bicyclo[3.1.1]hept-2-ene-2-ethanol may cause significant irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but health status should be considered.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children may increase risk. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
Toxicology Data
3 Endpoints
Research indicates moderate safety for topical use, though sensitivity varies.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates moderate safety for topical use, though sensitivity varies.
- Limited data on long-term effects
- Potential for skin irritation in sensitive individuals
- Regulatory reviews ongoing in various jurisdictions
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bicyclo[3.1.1]hept-2-ene-2-ethanol
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Bicyclo[3.1.1]hept-2-ene-2-ethanol
Year: 2020
Conclusion: Insufficient data to determine safe levels in food applications.
View Full Report →
FDA
Report: Regulatory Status of Bicyclo[3.1.1]hept-2-ene-2-ethanol
Year: 2022
Conclusion: No specific restrictions; safety evaluated on a case-by-case basis.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in cosmetics and supplements. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further studies
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should exercise caution.
Its use in food is limited and should comply with local regulations.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:24:55.285096Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.