6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
antioxidant · anti-inflammatory · skin conditioning · moisturizing
Kephalis
Molecular Formula
C14H24O2
Molecular Weight
224.34 g/mol
Category
natural extract
Bottom Line: Kephalis is generally considered safe for use in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are taking other supplements
✕ Avoid If:
- you have a known allergy to similar extracts
- you experience irritation upon use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H24O2 |
| Molecular Weight | 224.34 g/mol |
| Log P | 3.1 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, serums, moisturizers. Patch test before full application to avoid reactions.
Food
Herbal teas, nutritional bars. Consult with a healthcare provider before use.
Supplement
Capsules, powders. Follow dosage instructions to minimize risks.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Kephalis is generally well tolerated with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion of Kephalis may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Insufficient Data
Limited data on inhalation exposure to Kephalis; safety is uncertain.
ocular
ocular
Risk Level: Low to Moderate
Eye contact with Kephalis may cause mild irritation; rinse thoroughly if contact occurs.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to ingredients may lead to adverse reactions.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- breastfeeding — Generally safe but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate Kephalis without significant issues. |
| pregnant | Moderate | Pregnant individuals should exercise caution due to limited safety data. |
| infants_children | High | Children may be more sensitive to ingredients; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on effects during breastfeeding; caution is advised. |
Toxicology Data
3 Endpoints
Kephalis has been evaluated for safety in cosmetics and supplements, showing low toxicity in studies.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Kephalis has been evaluated for safety in cosmetics and supplements, showing low toxicity in studies.
- Generally recognized as safe in cosmetic formulations.
- Limited data on food safety, but no major concerns.
- Further research is needed for long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Kephalis
Year: 2021
Conclusion: Kephalis is safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Kephalis
Year: 2020
Conclusion: Insufficient data to determine safety in food applications.
View Full Report →
FDA
Report: GRAS Notification for Kephalis
Year: 2022
Conclusion: Generally recognized as safe for use in food products.
View Full Report →
Regulatory Status
Global
Kephalis is permitted in the US and UK, under review in the EU, with no data in Canada. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionUNDER REVIEW
Pending further studies
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
None
Frequently Asked Questions
Kephalis is generally safe, but individuals with sensitive skin should patch test first.
Kephalis is under review for food use; consult a healthcare provider before use.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:25:51.312636Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.