67.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
anti-inflammatory · antioxidant · colorant · skin conditioning
AZULENE, 1,2,3,5,6,7,8,8A-OCTAHYDRO-1,4-DIMETHYL-7-
Category
organic compound
Bottom Line: Azulene is generally considered safe for use in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to azulene
- you experience irritation upon use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Facial creams, serums, after-sun lotions. Generally safe for topical use; patch test recommended.
Pharmaceutical
Anti-inflammatory creams, topical analgesics. Use as directed; consult a healthcare provider if unsure.
Supplement
Herbal supplements, anti-anxiety formulations. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Azulene is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Insufficient Data
Limited data on oral ingestion; safety is not well established.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause mild irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: Moderate
Contact with eyes may cause irritation; rinse thoroughly if exposed.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to skin products; potential for irritation.
- sensitive_skin — Increased risk of adverse reactions; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- breastfeeding — Generally safe for topical use with precautions.
- elderly — Well tolerated but should monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; minimal risk of irritation. |
| pregnant | Low to Moderate | Limited data on safety during pregnancy; caution advised. |
| infants_children | Moderate | Higher sensitivity in young skin; potential for irritation. |
| breastfeeding | Low | Limited data; generally considered safe for topical use. |
| elderly | Low | Skin may be more sensitive; monitor for irritation. |
| sensitive_skin | Moderate | Higher risk of irritation; use with caution. |
Toxicology Data
3 Endpoints
Azulene is a compound with anti-inflammatory and soothing properties, commonly used in cosmetics.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | No irritation observed | CIR Safety Assessment (2012) |
| Sensitization | Non-sensitizing | Human patch test | No sensitization observed | SCCS Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Azulene is a compound with anti-inflammatory and soothing properties, commonly used in cosmetics.
- Derived from chamomile and other plants.
- Used for its calming effects on the skin.
- Generally recognized as safe in cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Azulene
Year: 2012
Conclusion: Azulene is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Azulene
Year: 2015
Conclusion: Azulene is safe for use in cosmetic products.
View Full Report →
FDA
Report: Food Ingredients and Their Safety
Year: 2020
Conclusion: No safety concerns for azulene in food applications.
View Full Report →
Regulatory Status
Global
Azulene is permitted for use in cosmetics and supplements across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Azulene is commonly used for its soothing and anti-inflammatory properties in skincare products.
Azulene is generally safe for sensitive skin, but patch testing is recommended before use.
Consult a healthcare provider before using azulene if you are pregnant or nursing.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:34:44.084251Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.