7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · fixative
Methyl Hexyl Cyclopentanone Carboxylate
Molecular Formula
C13H22O3
Molecular Weight
226.31 g/mol
Category
fragrance ingredient
Bottom Line: Methyl Hexyl Cyclopentanone Carboxylate is generally considered safe in cosmetics, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using multiple fragrance products
✕ Avoid If:
- you have a known allergy to fragrance ingredients
- you experience irritation or redness
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H22O3 |
| Molecular Weight | 226.31 g/mol |
| Log P | 3 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to minimize potential irritation.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using products containing this ingredient.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if you have skin sensitivities.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methyl Hexyl Cyclopentanone Carboxylate is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Insufficient Data
Limited data on oral toxicity; ingestion should be avoided.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause mild respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: Moderate
Contact with eyes may cause irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of skin irritation and sensitivity.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal irritation.
- breastfeeding — Generally safe with proper use.
- elderly — Low risk but should monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Low to Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young skin; potential for irritation. |
| breastfeeding | Low | Limited systemic absorption expected; generally safe. |
| elderly | Low to Moderate | Skin may be more sensitive; monitor for irritation. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methyl Hexyl Cyclopentanone Carboxylate is a fragrance ingredient with moderate safety assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Irritation | non-irritating | Human patch test | Low concern for irritation | CIR Safety Assessment (2020) |
| LD50 Oral | Not established | Not applicable | Insufficient data for acute toxicity | SCCS Opinion (2021) |
| Sensitization | non-sensitizing | Human sensitization study | Low concern for sensitization | FDA Regulatory Status (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methyl Hexyl Cyclopentanone Carboxylate is a fragrance ingredient with moderate safety assessments.
- Used widely in cosmetics and household products.
- Potential for skin irritation in sensitive individuals.
- Regulatory reviews indicate moderate safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methyl Hexyl Cyclopentanone Carboxylate
Year: 2020
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Methyl Hexyl Cyclopentanone Carboxylate
Year: 2021
Conclusion: Considered safe for use in cosmetic products with restrictions.
View Full Report →
FDA
Report: Regulatory Status of Methyl Hexyl Cyclopentanone Carboxylate
Year: 2022
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Methyl Hexyl Cyclopentanone Carboxylate is permitted in the US and UK, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
No specific regulations identified
Frequently Asked Questions
It may cause irritation in sensitive individuals, so patch testing is recommended.
It is often found in fragrances, lotions, and shampoos.
Yes, the EU has restrictions on its concentration in cosmetic products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:53:13.106949Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.