55.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Solvent · Stabilizer · Fragrance Ingredient · Emollient
BUTANAMIDE, 2-ETHYL-N-METHYL-N-(3-METHYLPHENYL)- CAT. 2 [H371]
Category
Chemical Compound
Bottom Line: Generally, butanamide is considered safe for use in cosmetics and pharmaceuticals, though caution is advised due to potential sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Formulated in products designed for sensitive skin
- Conducted patch tests prior to widespread use
⚠ Use with Awareness If:
- You have a history of skin sensitivities or allergies
- Using multiple products containing similar compounds
- Pregnant or nursing, consult a healthcare provider
✕ Avoid If:
- You experience irritation or allergic reactions
- Using on broken or compromised skin
- Combining with other harsh chemicals
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Generally safe in cosmetic formulations when used as directed.
Pharmaceutical
Topical ointments, prescription creams. Use under medical supervision to avoid adverse effects.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Dermal exposure may cause irritation or sensitization in some individuals.
oral
oral
Risk Level: High
Ingestion can lead to significant toxicity and adverse health effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation may cause respiratory irritation, particularly in sensitive individuals.
ocular
ocular
Risk Level: Moderate
Eye contact can cause irritation and discomfort, requiring rinsing.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to toxic effects.
- pregnant — Potential risks to fetal development.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with precautions.
- elderly — May tolerate with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults typically have a higher tolerance but should avoid ingestion. |
| pregnant | High | Potential risks to fetal development from systemic exposure. |
| infants_children | Very High | Children are more susceptible to toxic effects. |
| breastfeeding | Moderate | Limited data on transfer through breast milk. |
| elderly | Low to Moderate | Elderly may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
Butanamide has been evaluated for safety in cosmetics and pharmaceuticals, showing moderate concern for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Butanamide has been evaluated for safety in cosmetics and pharmaceuticals, showing moderate concern for sensitive individuals.
- Used in various cosmetic and pharmaceutical products.
- Moderate concern for skin irritation and sensitization.
- Regulatory assessments vary by jurisdiction.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Butanamide
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Butanamide
Year: 2018
Conclusion: Safety concerns noted for sensitive skin; further studies recommended.
View Full Report →
FDA
Report: Regulatory Status of Butanamide
Year: 2020
Conclusion: No specific restrictions; safe for use in regulated products.
View Full Report →
Regulatory Status
Global
Butanamide is permitted in the US and UK, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO DATA
None
Frequently Asked Questions
Butanamide may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using butanamide in supplements to ensure safety.
In the EU, butanamide is restricted to specific concentrations in cosmetic products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:29:16.355585Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.