7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · masking agent · odorant · fixative
Octahydro-Methyl-Methanonaphthalenone
Molecular Formula
C12H18O
Molecular Weight
178.27 g/mol
Category
fragrance
Bottom Line: Generally considered safe in cosmetics and household products, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated products
- Applied as directed
- Not used in high concentrations
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You have a history of allergies
✕ Avoid If:
- You experience irritation or allergic reactions
- You are using products for children
- You have respiratory issues
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H18O |
| Molecular Weight | 178.27 g/mol |
| Log P | 2.8 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in well-formulated products to minimize risks.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using products containing this ingredient.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider if unsure about use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Octahydro-Methyl-Methanonaphthalenone is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Octahydro-Methyl-Methanonaphthalenone may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with Octahydro-Methyl-Methanonaphthalenone can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by healthy adults.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is warranted. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Octahydro-Methyl-Methanonaphthalenone is a fragrance ingredient with moderate safety assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | Not sensitizing | Human repeated insult patch test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Octahydro-Methyl-Methanonaphthalenone is a fragrance ingredient with moderate safety assessments.
- Used in various cosmetic and household products
- Potential for skin sensitization
- Regulatory reviews indicate moderate safety
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at typical concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Safety acceptable when used in cosmetics under specified conditions.
View Full Report →
FDA
Report: Regulatory Status of Fragrance Ingredients
Year: 2021
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Octahydro-Methyl-Methanonaphthalenone is generally permitted in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It is primarily used as a fragrance ingredient in cosmetics and household products.
While generally safe, individuals with sensitive skin should use caution and perform patch tests.
Currently, there are no specific restrictions in major jurisdictions for this ingredient.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:26:00.130152Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.