55.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · intermediate · chemical precursor
BENZENE, 1-METHOXY-4-(1-PROPENYL)-, (E)-
Category
aromatic compound
Bottom Line: Benzene, 1-methoxy-4-(1-propenyl)- is generally considered safe in low concentrations, though caution is advised due to potential health risks.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied to intact skin without irritation
- Used in well-ventilated areas for household products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using products in poorly ventilated spaces
- You are pregnant or nursing
✕ Avoid If:
- You have a history of respiratory issues
- You are using on broken or irritated skin
- You are allergic to similar compounds
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, hair sprays. Use in low concentrations to minimize risks.
Food
Flavoring agents, food additives. Ensure compliance with food safety regulations.
Pharmaceutical
Topical medications, transdermal patches. Monitor for skin reactions during use.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to reduce inhalation risk.
Supplement
Herbal extracts, nutritional supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Skin contact with benzene derivatives may cause irritation or sensitization.
oral
oral
Risk Level: High
Ingestion of benzene derivatives can lead to serious health issues, including toxicity.
inhalation
inhalation
Risk Level: Very High
Inhalation of vapors can cause severe respiratory and neurological effects.
ocular
ocular
Risk Level: Moderate
Eye contact may cause irritation and potential damage to the cornea.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to toxic effects.
- pregnant — Potential risks to fetal development.
✔ Well-Tolerated Groups
- general_adult — Generally able to tolerate moderate exposure.
- elderly — May tolerate with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults may have varying sensitivities to benzene derivatives. |
| pregnant | High | Potential risks to fetal development from exposure. |
| infants_children | Very High | Children are more susceptible to toxic effects. |
| breastfeeding | Moderate | Potential transfer of harmful substances through milk. |
| elderly | Moderate | Elderly individuals may have compromised health. |
Toxicology Data
3 Endpoints
Benzene, 1-methoxy-4-(1-propenyl)- has been evaluated for safety in various applications, showing low toxicity at regulated levels.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzene, 1-methoxy-4-(1-propenyl)- has been evaluated for safety in various applications, showing low toxicity at regulated levels.
- Generally safe in low concentrations.
- Potential irritant at higher levels.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzene Derivatives
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations below 0.1%.
View Full Report →
SCCS
Report: Opinion on Benzene Derivatives
Year: 2018
Conclusion: Acceptable for cosmetic use with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2020
Conclusion: Safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status varies, with restrictions in the EU and UK but permitted in the US and Canada. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Limited to specific concentrations in cosmetics
European Union
European CommissionRESTRICTED
Use limited to specific applications
United Kingdom
UK GovernmentRESTRICTED
Similar to EU regulations
Canada
Health CanadaPERMITTED
Allowed in cosmetics under specific limits
Frequently Asked Questions
Generally safe in low concentrations, but always check product labels.
Potential risks include skin irritation and respiratory issues if misused.
Yes, there are concentration limits in cosmetics and food products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:39:16.561736Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.