6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · solvent · skin conditioning agent · humectant
Methoxytrimethylheptanol
Molecular Formula
C11H24O2
Molecular Weight
188.31 g/mol
Category
chemical compound
Bottom Line: Methoxytrimethylheptanol is generally considered safe for use in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation upon first use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H24O2 |
| Molecular Weight | 188.31 g/mol |
| Log P | 2.3 |
Common Use Cases
3 Categories
Cosmetic
Moisturizers, serums, sunscreens. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical creams, ointments. Use as directed; monitor for skin reactions.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Methoxytrimethylheptanol is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Methoxytrimethylheptanol may pose moderate risks based on limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with Methoxytrimethylheptanol may cause moderate irritation based on available evidence.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may occur. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methoxytrimethylheptanol has been evaluated for safety in cosmetics and supplements, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methoxytrimethylheptanol has been evaluated for safety in cosmetics and supplements, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Generally recognized as safe in cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methoxytrimethylheptanol
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Methoxytrimethylheptanol
Year: 2021
Conclusion: Considered safe for cosmetic use with no restrictions.
View Full Report →
FDA
Report: Regulatory Status of Methoxytrimethylheptanol
Year: 2022
Conclusion: No restrictions on use in cosmetics and supplements.
View Full Report →
Regulatory Status
Global
Methoxytrimethylheptanol is permitted for use in cosmetics and supplements across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test.
Consult your healthcare provider before using products with this ingredient if pregnant.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:35:17.656508Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.