7.0
ISS Score
B — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across 4 routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · flavoring agent · aroma enhancer
Rose Ketones
Category
fragrance
Bottom Line: Rose Ketones are generally considered safe for use in cosmetics and food, though individual reactions can vary based on sensitivity.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not applied to broken skin
- used in well-ventilated areas
- not ingested in large amounts
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or breastfeeding
- you have allergies to related compounds
- you are using other fragrances
✕ Avoid If:
- you experience irritation or allergic reactions
- you have a known sensitivity to ketones
- you are using on children without guidance
- you are consuming in excess amounts
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Fragrance oils, body lotions, shampoos. Use in moderation to avoid skin irritation.
Food
Flavoring agents, beverages, confectionery. Generally safe in food, but avoid excessive consumption.
Supplement
Dietary supplements, weight loss products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Rose Ketones are generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Rose Ketones may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Insufficient Data
Limited data exists on the inhalation safety of Rose Ketones.
ocular
ocular
Risk Level: Low
Contact with eyes may cause mild irritation, but serious effects are unlikely.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential adverse effects.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- elderly — Generally well tolerated in older adults.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically tolerate Rose Ketones well, with minimal side effects. |
| pregnant | Moderate | Limited studies on the effects of Rose Ketones during pregnancy. |
| infants_children | High | Children may be more sensitive to the effects of Rose Ketones. |
| breastfeeding | Low to Moderate | Limited data on the safety of Rose Ketones during breastfeeding. |
| elderly | Low | Elderly individuals generally tolerate Rose Ketones well. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Rose Ketones have been evaluated for safety in cosmetics and food applications, showing low toxicity in studies.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human clinical study | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Rose Ketones have been evaluated for safety in cosmetics and food applications, showing low toxicity in studies.
- Generally recognized as safe in cosmetics.
- Limited data on food safety.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Rose Ketones
Year: 2015
Conclusion: Rose Ketones are safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of Rose Ketones
Year: 2018
Conclusion: Rose Ketones are safe for use in food at specified limits.
View Full Report →
FDA
Report: Regulatory Status of Rose Ketones
Year: 2020
Conclusion: Rose Ketones are permitted for use in food and cosmetics under specific guidelines.
View Full Report →
Regulatory Status
Global
Rose Ketones are generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Rose Ketones are primarily used for their fragrance in cosmetics and as flavoring agents in food.
While generally safe, individuals with sensitive skin should perform a patch test before use.
Rose Ketones are considered safe in food, but moderation is advised to avoid potential side effects.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-02-15T03:16:49.061719Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.