4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
flavoring agent · fragrance ingredient · preservative · antimicrobial agent
Cinnamonitrile
Molecular Formula
C9H7N
Molecular Weight
129.16 g/mol
Category
chemical compound
Bottom Line: Cinnamonitrile is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not ingested in large amounts
- no known allergies to cinnamon
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other skin irritants
- you have a history of allergies
✕ Avoid If:
- you have a known allergy to cinnamon
- you experience irritation upon use
- you are using on children under 2
- you are taking anticoagulant medications
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C9H7N |
| Molecular Weight | 129.16 g/mol |
| Log P | 2 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, body lotions, lip balms. Use in moderation to avoid skin irritation.
Food
Flavoring agents, baked goods, spices. Generally safe in culinary amounts.
Supplement
Dietary supplements, herbal teas. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cinnamonitrile may cause mild skin irritation in some individuals upon contact.
oral
oral
Risk Level: Moderate
Ingestion of cinnamonitrile can lead to gastrointestinal discomfort and toxicity at high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of cinnamonitrile vapors may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Cinnamonitrile can cause significant irritation and potential damage to the eyes upon contact.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential toxic effects.
- pregnant — Limited data on safety during pregnancy.
- sensitive_skin — Increased risk of irritation.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with moderate use.
- elderly — Typically well tolerated but monitor for reactions.
- breastfeeding — Use cautiously with consultation.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential risks are not fully understood. |
| infants_children | Very High | Higher sensitivity to potential toxic effects; caution is advised. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; potential effects on infants are unclear. |
| elderly | Low | Generally well tolerated, but may have increased sensitivity. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cinnamonitrile has been assessed for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human clinical trial | No sensitization reactions reported | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cinnamonitrile has been assessed for safety in cosmetics and food applications, showing low toxicity.
- Generally recognized as safe in low concentrations.
- May cause skin irritation in sensitive individuals.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cinnamonitrile
Year: 2015
Conclusion: Cinnamonitrile is safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on Cinnamonitrile
Year: 2018
Conclusion: Cinnamonitrile is safe for use in food at typical levels.
View Full Report →
FDA
Report: Cinnamonitrile Regulatory Status
Year: 2020
Conclusion: Cinnamonitrile is permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Cinnamonitrile is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Cinnamonitrile is generally safe for skin use, but may cause irritation in sensitive individuals.
Yes, Cinnamonitrile is permitted in food products at typical levels, but moderation is advised.
If irritation occurs, discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:42:58.529466Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.