6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · solvent · stabilizer
3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One
Molecular Formula
C9H14O2
Molecular Weight
154.21 g/mol
Category
chemical compound
Bottom Line: 3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One is generally considered safe in cosmetics and food, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C9H14O2 |
| Molecular Weight | 154.21 g/mol |
| Boiling Point | 144.0°C |
| Solubility | soluble (in ethanol) |
| Log P | 1.9 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, scented lotions, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Use under medical supervision; potential for irritation.
Supplement
Herbal extracts, nutritional supplements. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One is generally considered low risk.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or sensitive individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally of very low risk, but irritation may occur.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher vulnerability to chemical exposure due to developing systems.
- pregnant — Altered sensitivities may affect safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure compared to sensitive populations. |
| pregnant | Moderate | Pregnant individuals may have altered sensitivities to substances. |
| infants_children | High | Children are more vulnerable to chemical exposures due to their developing systems. |
| breastfeeding | Low to Moderate | Substances can transfer through breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities due to health conditions. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One has been evaluated for safety in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One has been evaluated for safety in cosmetics and food applications.
- Safety assessments indicate low toxicity.
- May cause skin irritation in sensitive individuals.
- Regulatory reviews are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on 3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One
Year: 2020
Conclusion: Considered safe as a food additive within specified limits.
View Full Report →
SCCS
Report: Opinion on 3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One
Year: 2022
Conclusion: Safe for use in cosmetic products with restrictions.
View Full Report →
Regulatory Status
Global
3,4,4a,5,6,7,8,8a-Octahydrochromen-2-One is permitted in the US and Canada, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, it is safe for skin use, but patch testing is recommended for sensitive individuals.
Consult your healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:21:05.634781Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.