69.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
BICYCLO[2.2.1]HEPTAN-2-OL, 1,7,7-TRIMETHYL-,
Category
organic compound
Bottom Line: Generally regarded as safe when used appropriately, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- applied to intact skin without prior irritation
- consumed in food products within regulatory limits
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other active ingredients in skincare
✕ Avoid If:
- you experience irritation or allergic reactions
- you have a known sensitivity to similar compounds
- you are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally safe in regulated food applications.
Pharmaceutical
Topical ointments, medicated creams. Consult healthcare providers for use in medications.
Supplement
Dietary supplements, herbal products. Follow dosage recommendations to avoid adverse effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Bicyclo[2.2.1]heptan-2-ol is generally well tolerated with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Bicyclo[2.2.1]heptan-2-ol may pose moderate risks, particularly at higher doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally of very low risk, with minimal irritation reported.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects from chemical exposure.
- pregnant — Potential for altered sensitivity and effects on fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- elderly — Generally low risk but should be monitored for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure compared to vulnerable populations. |
| pregnant | Moderate | Pregnant individuals may have altered sensitivities to chemicals. |
| infants_children | High | Children are more susceptible to chemical exposure effects. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Elderly individuals may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl- is generally safe in regulated uses, though caution is advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Draize test | No significant irritation observed | CIR Safety Assessment (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl- is generally safe in regulated uses, though caution is advised.
- Used in cosmetics and food products.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments support its safe use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bicyclo[2.2.1]heptan-2-ol
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Bicyclo[2.2.1]heptan-2-ol
Year: 2019
Conclusion: Considered safe for use in food applications within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Bicyclo[2.2.1]heptan-2-ol
Year: 2021
Conclusion: No restrictions on use in cosmetics and food.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Possible side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:21:20.406389Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.