7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · solvent · aromatic compound · potential antimicrobial
Alpha-Cedrene
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
essential oil component
Bottom Line: Alpha-Cedrene is generally considered safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly diluted in formulations
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other skin irritants
✕ Avoid If:
- you have a known allergy to cedarwood oil
- you are using it in high concentrations
- you experience irritation or allergic reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Log P | 4.6 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, skin creams, shampoos. Use in diluted forms to minimize irritation risk.
Food
Flavoring agents, beverages. Generally recognized as safe in food applications.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for medicinal use.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using in households.
Supplement
Aromatherapy oils, dietary supplements. Use under guidance of a qualified professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Alpha-Cedrene is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Alpha-Cedrene may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; immediate rinsing is recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential irritants and allergens.
- pregnant — Limited safety data; consult healthcare provider.
- sensitive_skin — Increased risk of skin irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated; monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate Alpha-Cedrene with minimal risk. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to the effects of Alpha-Cedrene. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Elderly individuals typically tolerate Alpha-Cedrene well. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Alpha-Cedrene has been evaluated for safety in cosmetics and food, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Alpha-Cedrene has been evaluated for safety in cosmetics and food, showing low toxicity and minimal irritation potential.
- Low acute toxicity in animal studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Alpha-Cedrene
Year: 2012
Conclusion: Alpha-Cedrene is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Alpha-Cedrene
Year: 2018
Conclusion: Alpha-Cedrene is safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on Alpha-Cedrene
Year: 2019
Conclusion: Alpha-Cedrene is safe for use in cosmetic products.
View Full Report →
Regulatory Status
Global
Alpha-Cedrene is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should conduct a patch test first.
Yes, it is recognized as safe for use in food flavoring by EFSA.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:07:00.652739Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.