9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · antimicrobial agent · aromatic compound
Eucalyptol
Also known as: 1,8-Cineole, Eucalyptol, Eucalyptol Oil
Molecular Formula
C10H18O
Molecular Weight
154.25 g/mol
Category
essential oil
Bottom Line: Eucalyptol is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- used in well-ventilated areas
- not ingested in large amounts
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or breastfeeding
- you have a history of allergies
- you are using other essential oils
✕ Avoid If:
- you are allergic to eucalyptus
- you have asthma or respiratory issues
- you are using on children under 2 years
- you are taking anticoagulant medications
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H18O |
| Molecular Weight | 154.25 g/mol |
| Melting Point | 1.5°C |
| Boiling Point | 0.921°C |
| Solubility | soluble (in ethanol) |
| Density | 0.9267 g/cm³ |
| Log P | 2.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Use in moderation and perform a patch test.
Food
Flavoring agents, herbal teas. Generally safe in food, but avoid excessive amounts.
Pharmaceutical
Cough syrups, topical analgesics. Follow dosage instructions to avoid adverse effects.
Supplement
Essential oil capsules, herbal supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Eucalyptol is generally well tolerated on the skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of eucalyptol can lead to gastrointestinal upset; moderation is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of eucalyptol is typically safe, but may cause respiratory irritation in high concentrations.
ocular
ocular
Risk Level: High
Eucalyptol can cause significant irritation to the eyes; contact should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to essential oils; potential for adverse effects.
- pregnant — Limited data on safety during pregnancy; caution is advised.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated; however, individual sensitivities may vary.
- elderly — Generally well tolerated, but may have increased sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to essential oils; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but may have increased sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Eucalyptol is widely used in cosmetics and food, with moderate safety data supporting its use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2012) |
| Sensitization | not sensitizing | Human patch test | No sensitization observed | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Eucalyptol is widely used in cosmetics and food, with moderate safety data supporting its use.
- Generally recognized as safe in low concentrations.
- May cause skin irritation in sensitive individuals.
- Regulatory assessments support its use in various products.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Eucalyptol
Year: 2012
Conclusion: Eucalyptol is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Eucalyptol
Year: 2018
Conclusion: Eucalyptol is safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Eucalyptol in Food and Cosmetics
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Eucalyptol is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Eucalyptol is generally safe for skin use, but perform a patch test first.
Eucalyptol can be ingested in small amounts, but avoid large doses.
Some individuals may experience skin irritation or allergic reactions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:45:43.295618Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.