4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Fragrance ingredient · Flavoring agent · Solvent · Potential antimicrobial agent
Longifolene
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
Terpene
Bottom Line: Longifolene is generally considered safe in cosmetic and food applications, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other topical treatments
✕ Avoid If:
- you have a known allergy to terpenes
- you experience irritation after use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Log P | 5.1 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics, but patch test recommended.
Food
Flavoring agents, herbal teas. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical ointments, medicated creams. Use in pharmaceuticals should follow regulatory guidelines.
Supplement
Herbal supplements, essential oils. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Longifolene is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Longifolene may lead to gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of Longifolene vapors may cause mild respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- pregnant — Caution is advised due to limited safety data.
- infants_children — Higher sensitivity may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but monitoring is recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate Longifolene with minimal adverse effects. |
| pregnant | Moderate | Limited data on the effects of Longifolene during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to the effects of Longifolene. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Elderly individuals typically tolerate Longifolene well, but monitoring is advised. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation from dermal exposure. |
Toxicology Data
3 Endpoints
Longifolene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | SCCS Opinion (2019) |
| Sensitization | no sensitization observed | Human clinical study | Low sensitization potential | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Longifolene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Potential skin irritant in sensitive individuals.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Longifolene
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Longifolene
Year: 2018
Conclusion: Considered safe for use in food flavoring.
View Full Report →
SCCS
Report: Opinion on Longifolene
Year: 2019
Conclusion: Low concern for cosmetic use, but caution advised for sensitive skin.
View Full Report →
Regulatory Status
Global
Longifolene is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Longifolene may cause irritation in sensitive individuals; patch testing is recommended.
Yes, Longifolene is generally recognized as safe for use in food flavoring.
Potential side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:30:58.486476Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.