7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · solvent · stabilizer · thickener
3-O-[1-(3,3-Dimethylcyclohexyl)Ethyl] 1-O-Ethyl Propanedioate
Molecular Formula
C15H26O4
Molecular Weight
270.36 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe when used appropriately, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation or adverse reactions
- Using on open wounds or mucous membranes
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O4 |
| Molecular Weight | 270.36 g/mol |
| Log P | 4 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Use in moderation and patch test for sensitivity.
Food
Flavoring agents, food additives. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical ointments, prescription creams. Consult a healthcare provider for medicinal use.
Supplement
Dietary supplements, nutraceuticals. Use under guidance of a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but irritation may occur in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low, but prolonged exposure may cause respiratory irritation.
ocular
ocular
Risk Level: High
Eye contact can cause significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals; potential for adverse effects.
- pregnant — Limited data on safety during pregnancy; caution is advised.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated, but individual sensitivities may vary.
- elderly — Generally well tolerated, but monitor for any adverse reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for any adverse reactions. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Limited data available on safety and efficacy; further research needed.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Mild irritant | Rabbit - Dermal application | Moderate concern for sensitive skin | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human patch test | Low concern for sensitization | EFSA Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited data available on safety and efficacy; further research needed.
- Potential for skin irritation in sensitive individuals
- Regulatory assessments vary by region
- More studies required for comprehensive safety profile
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 3-O-[1-(3,3-Dimethylcyclohexyl)Ethyl] 1-O-Ethyl Propanedioate
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended levels.
View Full Report →
EFSA
Report: Scientific Opinion on 3-O-[1-(3,3-Dimethylcyclohexyl)Ethyl] 1-O-Ethyl Propanedioate
Year: 2022
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of 3-O-[1-(3,3-Dimethylcyclohexyl)Ethyl] 1-O-Ethyl Propanedioate
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe in food and cosmetics.
View Full Report →
Regulatory Status
Global
Generally permitted across major jurisdictions with no specific restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for use in cosmetics, though patch testing is recommended for sensitive skin.
Use with caution; patch test first to check for any adverse reactions.
Permitted in the US, EU, UK, and Canada with no specific restrictions noted.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:28:43.360050Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.