6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
chelating agent · antioxidant · skin conditioning agent · preservative
Ethyl Hydroxypyrone
Molecular Formula
C7H8O3
Molecular Weight
140.14 g/mol
Category
chemical compound
Bottom Line: Ethyl Hydroxypyrone is generally considered safe for use in cosmetics and food, though caution is advised in sensitive populations.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not applied to broken skin
- used in well-formulated products
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you experience irritation or allergic reactions
- you have a known hypersensitivity to similar compounds
- you are using on open wounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C7H8O3 |
| Molecular Weight | 140.14 g/mol |
| Melting Point | 90.0°C |
| Boiling Point | 289.0°C |
| Solubility | Soluble (in ethanol) |
| Log P | 0.8 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, sunscreens. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food preservatives. Considered safe for use in food products within regulatory limits.
Pharmaceutical
Topical treatments, oral supplements. Used in pharmaceuticals with established safety profiles.
Supplement
Antioxidant supplements, health boosters. Generally safe when used in recommended dosages.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Ethyl Hydroxypyrone is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Ethyl Hydroxypyrone may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Insufficient Data
Limited data exists on the inhalation safety of Ethyl Hydroxypyrone.
ocular
ocular
Risk Level: Low to Moderate
Eye contact may cause mild irritation, but significant effects are unlikely.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate Ethyl Hydroxypyrone without significant issues. |
| pregnant | Moderate | Limited studies on pregnant women; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Ethyl Hydroxypyrone has been evaluated for safety in cosmetics and food, showing low toxicity and good safety profiles.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2015) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl Hydroxypyrone has been evaluated for safety in cosmetics and food, showing low toxicity and good safety profiles.
- Low acute toxicity in animal studies.
- No significant adverse effects reported in cosmetic use.
- Regulatory bodies support its safe use in specified applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl Hydroxypyrone
Year: 2015
Conclusion: Ethyl Hydroxypyrone is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Ethyl Hydroxypyrone
Year: 2018
Conclusion: Ethyl Hydroxypyrone is safe for use in food at specified limits.
View Full Report →
FDA
Report: Food Ingredients and Colors
Year: 2020
Conclusion: Ethyl Hydroxypyrone is generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Ethyl Hydroxypyrone is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Yes, it is permitted in food products within established safety limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:37:39.014363Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.