6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · skin conditioning agent · anti-inflammatory agent · antioxidant
Bisabolene
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
natural compound
Bottom Line: Bisabolene is generally considered safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not applied to broken skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other topical medications
✕ Avoid If:
- you have a known allergy to bisabolene
- you experience irritation or adverse reactions
- you are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Solubility | Insoluble (in ethanol) |
| Log P | 4.7 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, herbal teas. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Use under medical supervision for therapeutic purposes.
Supplement
Herbal supplements, essential oils. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Bisabolene is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Low to Moderate
Oral ingestion of bisabolene is typically safe in small amounts, but excessive intake may pose risks.
inhalation
inhalation
Risk Level: Low
Inhalation exposure to bisabolene is generally low risk, with minimal respiratory irritation reported.
ocular
ocular
Risk Level: Moderate
Contact with eyes may cause irritation; caution is advised to avoid exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
- sensitive_skin — Increased risk of irritation for those with sensitive skin.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- breastfeeding — Generally considered safe with minimal risk.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for bisabolene exposure. |
| pregnant | Low to Moderate | Limited data on bisabolene effects during pregnancy; caution is advised. |
| infants_children | Moderate | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low | Limited evidence suggests bisabolene is safe during breastfeeding. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Bisabolene is a natural compound with various applications in cosmetics and food, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | CIR Safety Assessment (2012) |
| Sensitization | non-sensitizing | Human patch test | No sensitization observed | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bisabolene is a natural compound with various applications in cosmetics and food, showing low toxicity.
- Natural compound derived from plants.
- Used in cosmetics for fragrance and skin benefits.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bisabolene
Year: 2012
Conclusion: Bisabolene is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Bisabolene
Year: 2015
Conclusion: Bisabolene is considered safe for use in food products.
View Full Report →
FDA
Report: Food Ingredients and Their Safety
Year: 2020
Conclusion: Bisabolene is generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Bisabolene is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Bisabolene is generally safe, but patch testing is recommended for sensitive skin.
Yes, bisabolene is recognized as safe for use in food applications.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:31:22.105525Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.