69.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · flavoring agent · solvent
BICYCLO[4.1.0]HEPT-3-ENE, 3,7,7-TRIMETHYL-
Category
organic compound
Bottom Line: Generally regarded as safe in cosmetics and food, though individual reactions may vary based on sensitivity.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair products. Use in moderation and patch test for sensitivity.
Food
Flavoring agents, food additives. Generally safe when used as intended in food products.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Bicyclo[4.1.0]hept-3-ene, 3,7,7-trimethyl- is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks due to limited data on toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but data is limited.
ocular
ocular
Risk Level: Very Low
Eye contact with this compound is considered very low risk based on available evidence.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but individual health should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Bicyclo[4.1.0]hept-3-ene, 3,7,7-trimethyl- is used in cosmetics and food, with limited safety data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Bicyclo[4.1.0]hept-3-ene, 3,7,7-trimethyl- is used in cosmetics and food, with limited safety data.
- Limited studies on human safety.
- Potential for skin irritation.
- Regulatory reviews are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bicyclo[4.1.0]hept-3-ene
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Bicyclo[4.1.0]hept-3-ene
Year: 2020
Conclusion: Considered safe for use in food applications within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Bicyclo[4.1.0]hept-3-ene
Year: 2022
Conclusion: No specific restrictions; generally recognized as safe.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally considered safe in cosmetics, though patch testing is recommended.
Use with caution; patch test first to check for any adverse reactions.
Discontinue use immediately and consult a healthcare professional if needed.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:26:45.864737Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.