6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · solvent · fixative · flavoring agent
Cyclopentadecanone
Molecular Formula
C15H28O
Molecular Weight
224.38 g/mol
Category
fragrance compound
Bottom Line: Cyclopentadecanone is generally considered safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- Pregnant or breastfeeding
✕ Avoid If:
- You are allergic to similar fragrance compounds
- You have a history of skin irritation
- Using in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H28O |
| Molecular Weight | 224.38 g/mol |
| Log P | 5.8 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, beverages. Use within established food safety limits.
Pharmaceutical
Topical creams, ointments. Monitor for skin reactions when used in medications.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclopentadecanone is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks; limited data on long-term effects is available.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but data on chronic exposure is limited.
ocular
ocular
Risk Level: Very Low
Eye contact with cyclopentadecanone generally results in minimal irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse reactions.
- elderly — Generally well tolerated, but individual sensitivities may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for various substances. |
| pregnant | Moderate | Limited data on the effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Elderly individuals may have varying sensitivities to substances. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cyclopentadecanone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclopentadecanone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Generally recognized as safe in regulated amounts.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclopentadecanone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclopentadecanone
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: Opinion on Cyclopentadecanone
Year: 2019
Conclusion: No safety concerns at recommended use levels.
View Full Report →
Regulatory Status
Global
Cyclopentadecanone is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test products containing it.
Consult a healthcare provider before using products with this ingredient during pregnancy.
It is often found in perfumes, lotions, and food flavorings.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:03:26.583372Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.